Synthesis and evaluation of novel multi-target compounds for the treatment of Alzheimer’s disease

girl on a mountain looking at the sun rise

Alzheimer’s disease (AD) is the most common neurodegenerative disease It is often characterised by cognitive deficiency and memory loss.

Award
MRes | MPhil | PhD | MSc by Research
Start Date
Usually February and October - at individual School's discretion

Summary

The prevalence of AD is age-related and with an ageing world population and increased life expectancy, it is estimated that by 2050, there will be around 100 million AD patients. Hence it remains a primarily unmet medical need worldwide, while causing a huge financial burden for families, health care systems, and associated social care. Pathology of AD involves multiple and complex factors. There is no cure for this disease and there are currently four drugs in the clinic that manage only the symptoms of AD. Because of the multifactorial nature of AD, the well accepted theory of “one molecule and one target” approach in drug discovery has, so far, not provided any effective drugs to cure a complex disease like AD.

For the last two decades, the concept of a multi-target drug hypothesis has been gaining much attention among scientists working in drug design and discovery.  Thus, by making a compound that can target more than one or two factors that contribute to AD, then we hypothesise that this approach would yield a more effective therapeutic drug. Furthermore, it would provide better patient compliance since taking only one tablet is required.

Recently, we have identified lead compounds with multi target properties. The latter include strong antioxidant properties, with the ability to provide cellular protection from oxidative stress and inhibitory activities against choline esterase enzymes. The latter are well-known factors contributing to AD. In this multidisciplinary project we aim to synthesise a library of novel compounds for optimum activity and to study the mechanism of action of the most active compound and to confirm the multi target directed hypothesis.

Supervisor

Discuss this further with the potential supervisor for this research degree:

Research Theme

Find other Research Degrees in the same theme:

About our Research Degrees

We welcome specific ideas from applicants for a potential research degree topic. The University offers a number of potential self-funded topics in each School which you could consider developing your research project around.

It is not unusual for a proposed research degree topic to evolve as you progress through the application stage and even your future studies. This ensures the best match of your academic/professional experience with that of your supervisory team.   

Occasionally, the University will also advertise available funded studentships, for very specific topics or subjects:

If you need any further support prior to applying, please email researchdegrees@rgu.ac.uk

 

Entry Requirements for Research Degrees

Normal entry requirements are a first or upper second class honours degree from a University of the United Kingdom, or from an overseas University, or degree equivalent qualification, subject to the approval of Robert Gordon University.

Applicants holding other qualifications shall be considered on their merits and in relation to the nature and scope of the proposed research programme. 

Applicants will normally register for an MSc/PhD or MRes/PhD with transfer to PhD dependent on satisfactory progress. However, applicants who already possess a Master’s degree which includes a significant research component could be registered directly for a PhD, subject to a satisfactory research proposal, and clear evidence of research expertise. 

Some Research Degree Topics require employment experience, research experience and/or transcripts for international qualifications.

Contact admissions@rgu.ac.uk to see if you are eligible.

English Language

Any applicant whose first language or language of previous University-level instruction is not English must normally demonstrate competence in English. This should be a score of IELTS 6.5 with 6.5 in all elements, or an approved equivalent.

We accept a variety of in-country and secure English language tests, find out more:

Please note, some courses may require a higher standard of English than stated in this page. Contact admissions@rgu.ac.uk for further information.

 

For Academic Year 2022/2023

UK/EU Students

  • Full time - £4,596 per academic year
  • Part time MPhil/PhD - £2,760 per academic year
  • Part time MRes/MSc by research - £2,298 per academic year

International Students

  • Full time - £17,000 per academic year
  • Part-time MPhil/PhD - £10,200 per academic year
  • Part-time MRes/MSc by research - £8,500 per academic year

Additional Costs

The following course-related costs are not included in the course fees:

Alumni Discount

Robert Gordon University is delighted to offer a 20% loyalty discount on course fees for all alumni who have graduated from RGU.

Scholarships and Financial Awards 

Postgraduate research students will normally make their own arrangements for payment of fees. However you may qualify for a scholarship or financial award:

Funded Studentships

Occasionally, the University will also advertise avaliable funded studentships, for very specific topics or subjects:

Disclaimer

For new intakes course fees are reviewed and published annually for each mode of delivery. Tuition fees are fixed for the duration of a course at the rate confirmed in the offer letter. For further information see: 

 

All applications should be made via the University's online application for research students.

Before you apply, find out more about the application process, deadlines, time frames, routes and durations:

Our Research degrees usually start in February and October each year. There are no formal deadlines for you to submit your application, though we recommend you submit it as early as possible in order to ensure we can help you join us at your preferred time. 

Completed application forms should be accompanied by:

  • Two academic references
  • A transcript or mark sheet for all graduate qualifications
  • A draft research proposal, or at least a short summary to indicate the potential area of research (Refer to Section 8 of the Application Form)

For applicants whose first language or language of university education is not English, applications must include:

  • Certificate of English language competency score of IELTS 6.5 and 6.5 in all elements, or an approved equivalent. 
  • Students who can demonstrate successful completion of tertiary (university or college) studies in a country whose national language is English, may be exempted from this requirement.
 

Ready to start this Research Degree? Find out about our entry requirements, application dates and how to apply.

Apply for a Research Degree

Have a question about this Research Degree? Get in touch with our Student Admissions Service and we'll do our best to help.

Get in touch

Cookie Consent