Dysregulation of the blood clotting pathway
Uncontrolled bleeding is the leading cause of preventable death in young persons under the age of 44. Improving our knowledge and understanding of the cellular and molecular mechanisms that cause uncontrolled bleeding, will identify novel treatments, improve patient care and reduce mortality.
Research Opportunities
Summary
Opportunities are available for projects investigating the role of the blood clotting pathways (coagulation and fibrinolysis) in acquired and inherited bleeding disorders. Blood samples from healthy volunteers will be manipulated to model bleeding pathologies and specialised haemostasis techniques used to unpick the mechanism of action. The in vitro models will be complemented by use of patient blood samples to validate results. Techniques include monitoring blood clot formation and degradation, quantifying thrombin generation, forming model blood clots under blood flow conditions, isolating blood cells from human samples, analysing blood cell activation and microscopy.
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