Profile

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Title: Dr
First Name: Iain
Surname: Rowe
Position: Lecturer
Telephone: +44 (0) 1224 262546
Email:
ORCID: ORCID Icon http://orcid.org/0000-0002-0148-5332

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Roles and Responsibilities

  • Lecturer at the School of Pharmacy and Life Science


Key research interests

Dr Rowe's research interests are rooted in physiology and pharmacology. His key research skills include Single ion channel recording, Electrophysiology, Potassium channel expression systems and slice recording systems. Specific interests include:

  • Potassium channel physiology
  • Potassium channel pharmacology
  • Metabolic regulation of ion channels
  • Ion channels in pulmonary tissue
  • Hypothalamic control of appetite


Current research

Dr Rowe's current project collaborations include:

  • Prof Mike Shipston, Edinburgh University: BKCa channel physiology and pharmacology
  • Prof Gareth Leng, Edinburgh University: Appetite and neuronal models
  • Dr Nancy Sabatier, Edinburgh University: Appetite regulation
  • Prof Rory Duncan, Heriot-Watt University: Single molecule imaging
  • Prof Mike Ludwig, Edinburgh University: Vasopressin


Key Publications

  1. Ciprian Dopinescu, Helene Widmer, Iain Rowe, Cherry Wainwright, Dorothy McCaig & Stuart Cruickshank. Hypoxia sensitivity of a voltage-gated potassium current in porcine intrapulmonary vein smooth muscle cells. Am. J.Physiol. (Lung Cell.Mol.Physiol.) Published ahead of print July 6, 2012, doi:10.1152/ajplung.00157.2012 
  2. Fiona Ross, J. Nicole Rafferty, Mark L. Dallas, Christopher N. Wyatt, Oluseye Ogunbayo, Naoko Ikematsu, Heather McClafferty, Lijun Tian, Helene Widmer, Iain C.M. Rowe, Michael J. Shipston, Chris Peers, D. Grahame Hardie, A. Mark Evans. (2011) BKCa channel α-subunit splice variants are differentially modulated by AMP-activated protein kinase dependent phosphorylation. J.Biol.Chem. 286, 11929-11936
  3. Owen Jeffries, Nina Geiger, Iain C.M. Rowe, Lijun Tian, Heather McClafferty, Lie Chen, Danlei Bi, Hans Guenther Knaus, Peter Ruth  & Michael J. Shipston. (2010) Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium- activated potassium (BK) channels. J.Biol.Chem. 285, 33307-33314
  4. Lie Chen, Iain C. M. Rowe, Hans-Guenther Knaus, Peter Ruth & Michael J. Shipston. (2010) Membrane trafficking of large conductance calcium-activated potassium (BK) channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker.  J.Biol.Chem. 285, 23263-23273
  5. Saleem F, Rowe ICM & Shipston MJ. (2009) Characterisation of BK channel splice variants using membrane potential dyes. Br.J.Pharmacol. 156, 143-152
  6. Tian L, Jeffries OJ, McClafferty H, Molyvdas A, Rowe ICM, Saleem F, Chen L, Greaves J, Chamberlain LH, Knaus H-G, Ruth P & Shipston MJ. (2008) Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels. Proc. Natl. Acad. Sci. USA 105, 21006-21011.
  7. N. Sabatier, I.C.M. Rowe & G. Leng (2007) The role of intrahypothalamic release of oxytocin in the regulation of appetite. Biochemical Society Transactions. 35, 1247-1251   
  8. Elizabeth Vernon-Wilson, Frederic Aurade, Lijun Tian, Iain Rowe, Michael Shipston, John Savill & Simon Brown (2007) CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells. J. Leukocyte Biol. 82, 1278-1288
  9. McCartney, C.E., Huibant, J-M., McClaffery, H., Rowan, E.G., Shipston, M.J. & Rowe, I.C.M. (2005) A cysteine rich motif confers hypoxia sensitivity onto mammalian large conductance voltage and calcium activated (BK) channel α subunits. Proc. Natl. Acad. Sci. USA. 102, 17870-17875
  10. Widmer, H.A., Rowe, I.C.M. & Shipston, M.J. (2003) Conditional protein phosphorylation regulates BK channel activity in rat cerebellar Purkinje neurons. J.Physiol. 552, 379-391.
  11. Lee, K., McKenna, F., Rowe, I.C.M. & Ashford, M.L.J. (1997) The effect of neuroleptic and tricyclic drugs on BKCa channel activity in rat isolated cortical neurones. Br. J. Pharmacol. 121, 1810-1816.
  12. Rowe, I.C.M., Lee, K., Khan, R.N. & Ashford, M.L.J. (1997) Englitazone inhibits KATP and non-selective cation channels in CRI-G1 insulin-secreting cells. Br. J. Pharmacol.  121, 531-539.
  13. Rowe, I.C.M., Treherne, J.M. & Ashford, M.L.J. (1996) Activation by intracellular ATP of a potassium channel in neurones from rat basomedial hypothalamus. J.Physiol. 490.1, 97-113.
  14. Lee, K., Khan, R.N., Rowe, I.C.M., Ozanne, S.E., Hall, A.C., Hales, C.N. & Ashford, M.L.J. (1996) Ciclazindol inhibits KATP channels and stimulates insulin secretion in CRI-G1 insulin-secreting cells. Mol. Pharmacol. 49, 715-720.
  15. Lee, K., Dixon, A.K., Rowe, I.C.M., Ashford, M.L.J. & Richardson, P.J.(1996) Expression of the high affinity sulphonylurea receptor and associated KATP channels in nerve terminals of the rat motor cortex. J. Neurochem.. 66, 2562-2571.
  16. Rowe, I.C.M., Boden, P.R. & Ashford, M.L.J. (1996) Potassium channel dysfunction in hypothalamic glucose-receptive neurones of obese Zucker rats. J. Physiol. 497.2, 365-377.
  17. Bond, C.T., Ammalla, C., Ashfield, R., Blair, T.A., Gribble, F., Khan, R., Lee, K., Proks, P., Rowe, I.C.M., Sakura,H., Ashford, M.L.J., Adelman, J.P. & Ashcroft, F.M. (1995). Cloning and functional expression of the cDNA encoding an inwardly-rectifying potassium channel expressed in pancreatic B-cells and in the brain. FEBS Letts.. 367, 61-66.
  18. Lee, K., Dixon, A.K., Rowe, I.C.M., Ashford, M.L.J. & Richardson, P.J. (1995) Direct demonstration of sulphonylurea-sensitive KATP channels on nerve terminals of the rat motor cortex.  Br. J. Pharmacol.  115, 385-388.
  19. Lee, K., Rowe, I.C.M. & Ashford, M.L.J. (1995)  NS 1619 activates BKCa channel activity  in rat cortical neurones. Eur. J. Pharmacol.  280, 215-219.
  20. Lee, K., Rowe, I.C.M. & Ashford, M.L.J. (1995) Characterisation of an ATP-modulated large conductance Ca2+-activated K+ channel present in rat cortical neurones. J. Physiol. 488.2, 319-337.
  21. Lee, K., Ozanne, S.E., Rowe, I.C.M., Hales, C.N. & Ashford, M.L.J. (1994) The effects of trypsin on ATP-sensitive potassium channel properties and sulfonylurea receptors in the CRI-G1 insulin-secreting cell line. Mol. Pharmacol. 45. 176-185.
  22. Wareham, A.C., Rowe, I.C.M. & Whittle, M.A. (1990) Sarcolemmal K+ channel activity in developing rat skeletal muscle membranes. J.Neurol. Sci. 96, 321-331.
  23. Rowe, I.C.M., Wareham, A.C. & Whittle, M.A (1990). K+ channel activity in sarcolemmal vesicles formed from skeletal muscle fibres of normal and dystrophic mice. J. Neurol. Sci. 98, 51-61.

Communications and Abstracts:

  1. Iain C.M. Rowe, Fozia Saleem, Owen Jefferies, Claire McCartney, Heather McClaffery, Edward G.Rowan, Rory Duncan & Michael J. Shipston. (2011) Investigating structural rearrangement of the BK channel RCK1-RCK2 linker using fluorescence lifetime imaging microscopy. Biophysical Society Meeting, Baltimore, USA
  2. Chris Saunders, Helene Widmer, Mike Ludwig & Iain Rowe (2011) Vasopressin and vasopressin receptor expression and distribution in the rodent retina. European Congress of Endocrinology, Rotterdam, The Netherlands
  3. Nancy Sabatier, Iain Rowe, Gareth Leng (2010) Investigating the properties and network activity of rat hypothalamic neurones in vivo. Scottish Neuroscience Group Meeting, Strathclyde
  4. Banks, R. W., Simon, A., Rowe, I. C. & Bewick, G. S (2009). P/Q type Ca2+ channels and KCa channels regulate afferent discharge frequency in spindle mechanosensory terminals. Society for Neuroscience, Chicago, IL,
  5. Iain C.M. Rowe, Fozia Saleem, Heather McClafferty and Michael J. Shipston (2009)
  6. The identification of cysteine residues that influence both the calcium and hypoxia sensitivity of the STREX splice variant of BK channel α-subunits. New York Academy of Sciences meeting on “Hypoxia: From Molecules to Malady”
  7. Tian L, Jeffries OJ, McClafferty H, Molyvdas A, Rowe ICM, Saleem F, Chen L, Shipston MJ. (2009) Palmitoylation controls BK channel regulation by phosphorylation. IUPS in Kyoto  
  8. Nina Geiger, Owen Jeffries, Fozia Saleem, Iain Rowe, Michael Shipston (2009)
  9. Screening the effects of cysteine mutations on BKCa channel function and trafficking. Proceedings of the British Pharmacological Society Vol 7: Issue.  
  10. Owen Jeffries, Fozia Saleem, Iain Rowe, Michael Shipston (2009) BKCa ion channel screening using voltage-sensitive dyes. Joint meeting of the BPS and RSC on “Ion channels as therapeutic targets”.
  11. 35.   Fozia Saleem, Iain C.M. Rowe and Mike J. Shipston (2007) The identification of amino acid residues that influence both the calcium and hypoxia sensitivity of the STREX splice variant of BK channel α-subunits. Abstract for the Society for Neuroscience meeting in San Diego 2007
  12. Fozia Saleem, Iain C.M. Rowe and Mike J. Shipston. (2007) Screening of BKCa splice variants using voltage-sensitive dyes. Abstract for Life Sciences 2007 in Glasgow
  13. Fozia Saleem, Iain C.M. Rowe and Mike J. Shipston. (2007) Magnesium and lithium ions modulate the activity of the large conductance calcium-activated potassium (BKCa) channel STREX splice variant expressed in the HEK 293 cell line. J.Physiol.
  14. Rowe, I.C.M.,  MacDonald, S. H-F., Menzies, J.R.W.,. Shipston, M.J , Cruickshank,  S.F. & Knott, R. (2006) The expression of large conductance potassium channels in rodent isolated retinal microvasculature. Abstract for the British Microcirculation Society Meeting (April 2006)
  15. McCartney, C.E,  Rowan E.G. & Rowe I.C.M. (2004) The effects of redox agents and hypoxia on the activity of neuronal large conductance calcium-activated potassium (BKCa) channels expressed in AtT20 and HEK 293 cell lines.  Abstract to the Society for Neuroscience. San Diego , USA.
  16. McCartney, C.E,  Rowan E.G. & Rowe I.C.M. (2003)  The effects of hypoxia on the activity of neuronal large conductance calcium-activated potassium (BKCa) channels in AtT20 and HEK 293 cell lines.  J.Physiol. 551P, C40
  17. McCartney, C.E., Rowan, E.G. & Rowe, I.C.M. (2002) The effects of hypoxia on the activity of neuronal large conductance calcium-activated potassium channels. Br.J.Pharmacol. 137, 41P. 
  18. McCartney, C.E., Rowan, E.G. & Rowe, I.C.M. (2002) The effects of hypoxia and anoxia on the activity of neuronal large conductance calcium-activated potassium channels. Abstract to the Society for Neuroscience. Orlando, USA
  19. Robinson, S.M, Rowe, I.C.M. & Shipston M.J. (2000) Nitric oxide does not directly activate cloned BK channel a-subunits expressed in HEK-293 cells. J. Physiol. 527P
  20. Rowe, I.C.M., Kelly, T. & Spanswick D. (1999) Nitric oxide activates potassium channels in sympathetic preganglionic neurones in rat spinal cord slices. J. Physiol. 521P 96P.
  21. Rowe, I.C.M., Spanswick, D & Ashford, M.L.J (1998) The characterization of potassium channels present in glucose- and sulphonylurea-sensitive hypothalamic neurones in isolation and in brain slices of the mf1 mouse. J.Physiol. 509P, 152-153.
  22. Rowe, I.C.M., Kelly, T., Logan, S.G. & Spanswick, D. (1998) Potassium channel activation by nitric oxide in electrotonically coupled rat sympathetic preganglionic neurones. Abstract to the Society for Neuroscience.  Los Angeles, USA.
  23. McKenna, F., Smith, M.A., Rowe, I.C.M., Richardson, P.J. & Ashford, M.L.J. (1996). Identification of distinct potassium channels in rat motor cortex presynaptic terminals. J.Physiol. 495P, 87P.
  24. Herson, P.S., Dulock, K.A., Rowe, I.C.M. & Ashford, M.L.J. (1996).  Divalent cation modulation of a ßNAD+-dependent non-selective cation channel in CRI-G1 insulin-secreting cells. J. Physiol. 495P, 86P.
  25. Dulock, K.A., Herson, P.S., Rowe, I.C.M. & Ashford, M.L.J. (1996).  Activation of a NAD+-activated non-selective cation channel by ATP and its non-hydrolysable analogues in CRI-G1 insulin secreting cells. Br.J. Pharmacol. 119, NoSS, P371.
  26. Rowe, I.C.M. & Ashford, M.L.J. (1996). The inhibition of KATP channels in the rat insulinoma cell line CRI-G1 by the intracellular application of purinergic antagonists. Br. J. Pharmacol.119, NoSS, P294.
  27. Lee, K., Dixon, A.K., Rowe, I.C.M., Ashford, M.L.J. & Richardson, P.J. (1995). Sulphonylurea-sensitive KATP channels on a novel isolated nerve terminal preparation of rat motor cortex. J. Physiol. 483, 66P.
  28. Rowe, I.C.M., Lee, K. & Ashford, M.L.J. (1995). The effects of neuroleptic and tricyclic drugs on BKCa channel activity in rat isolated cortical neurones. J. Physiol. . 483, 67P.
  29. Lee, K, Dixon, A.K., Rowe, I.C.M., Ashford, M.L.J. & Richardson, P.J. (1995). Sulfonylurea sensitive KATP channels on nerve-terminals of the rat motor cortex. J. Neurochem. 65, No.SS, S30.
  30. Lee, K, Khan, R.N., Rowe, I.C.M. & Ashford, M.L.J. (1995). Inhibition of KATP channel currents by ciclazindol in the CRI-G1 insulin secreting cell line. Br. J. Pharmacol. 116, NoSS, 172P.
  31. Rowe, I.C.M., Lee, K., Lloyd, C. & Ashford, M.L.J. (1995). ?-antagonists inhibit BKCa channel activity in rat isolated cortical neurones. J. Physiol. 487P, P196.
  32. Robertson, S.J., Woodward, R., McKenna, F., Rowe, I.C.M., Ashford, M.L.J. & Murrell-Lagnado, R.D. (1995). Expression of heteromeric inwardly rectifying K+ channels of the Kir3 family in Xenopus oocytes. J.Physiol.  489P, P58.
  33. Lee K., Rowe, I.C.M. & Ashford, M.L.J. (1994). ATP modulates the activity of a large conductance calcium-activated potassium channel in isolated neurones from the rat motor cortex. J. Physiol. 475. 145P.
  34. Lee, K., Rowe, I.C.M. & Ashford, M.L.J. (1994) Pharmacological modulation of the trypsinized KATP channel in the CRI-G1 insulin-secreting cell-line. Br. J. Pharmacol. 112. 370P.
  35. Lee, K., Rowe, I.C.M. & Ashford, M.L.J. (1994). Adenosine and cytidine nucleotides activate KCa channels in rat isolated cortical neurones. J. Physiol. 477. 83P.
  36. Ozanne S.E., Lee, K., Hall, A.C., Rowe, I.C.M., Ashford, M.L.J. & Hales, C.N. (1994). Ciclazindol inhibits KATP channels in CRI-G1 insulin-secreting cells. Diabetic Med. 11, Suppl 1, p71.
  37. Rowe, I.C.M. (1994) Invited speaker at the 14th European Winter Conference on Brain Research. 'Non-classical KATP channels of hypothalamic glucose-receptive neurones.'
  38. Rowe, I.C.M. Treherne, J.M. & Ashford, M.L.J. (1993) The effects of adenosine nucleotides on the ATP-activated K+ channel in rat isolated hypothalamic neurones. J. Physiol. 459, 54P.
  39. Rowe, I.C.M., Boden, P.R. & Ashford, M.L.J.(1993) Potassium channel dysfunction in hypothalamic neurones of genetically obese rats. J.Physiol. 459, 398P.
  40. Rowe, I.C.M. & Ashford, M.L.J. (1993). The effects of adenosine and guanine nucleotides on the ATP-activated K+ channel in rat isolated hypothalamic neurones. J. Physiol. 467, 268P.
  41. Rowe, I.C.M. & Ashford, M.L.J. (1992) The effect of Mg2+ ions on the inhibition of the KATP channel by adenosine nucleotides in rat isolated hypothalamic neurones. J.Physiol. 446, 274P.
  42. Ashford, M.L.J., Rowe, I.C.M. & Treherne, J.M. (1992) ATP-regulated K+ channels in rat hypothalamic neurones. Eur. J. Neurosci. S5, p81.
  43. Wareham, A.C., Whittle, M.A. & Rowe, I.C.M. (1989) ATP-regulated K+ channels in rat neonate skeletal muscle. Smith Kline & French Research Symposium on Ion Transport, p321-322.  Eds. D.Keeling, C.Benham. Academic Press, London.
  44. Rowe, I.C.M., Wareham, A.C. & Whittle, M.A (1989). K+ channel activity in sarcolemmal vesicles formed from skeletal muscle fibres of normal and dystrophic mice. Smith Kline & French Research Symposium on Ion Transport, p322-323.  Eds. D.Keeling, C.Benham. Academic Press, London.
  45. Rowe, I.C.M., Wareham, A.C. & Whittle, M.A. (1988). Sarcolemmal ultrastructure during enzymatic treatment of mammalian muscle to produce vesicles. J. Physiol. 413, 6P.
  46. Robinson, N.L., Rowe, I.C.M. & Sedgwick, E.M. (1987). An automated microcomputer based system for estimating spinal inhibition in man. J.Physiol. 387, 8P.
  47. Carter, M.R, Rowe, I.C.M. & Sedgwick, E.M. (1987). D1 inhibition in man with spinal cord injury. J.Physiol. 396, 157P.
  48. Rowe, I.C.M., Sedgwick, E.M. & Robinson, N.L. (1986). Computer controlled H-reflex measurement in the assessment of inhibition in spasticity in man. Electroenceph. clin. Neurophysiol. 61 (3), pS64.
  49. Cole, J.D., Philip, H.I., Rowe, I.C.M. & Sedgwick, E.M. (1986). The effect of variable gain visual feedback on the stability of finger position during isometric hold test in normal man and patients without peripheral feedback. J. Physiol. 373, 12P.