Profile

Morag McFadyen
Title: Dr
First Name: Morag CE
Surname: McFadyen
Position: Lecturer, Teaching fellow
Telephone: +44 (0)1224 262532
Email:
Linkedin: LinkedIn Icon http://www.linkedin.com/pub/morag-mcfadyen/12/a8b/105
ORCID: ORCID Icon http://orcid.org/0000-0002-2597-5918

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Dr McFadyen is a lecturer and teaching fellow at the School of Pharmacy and Life Sciences. Her current research interests lie in the application of science to practice and innovative educational pedagogies.

Duties and Responsibilities

  • Module co-ordinator for AS2028 Nutritional Research Methods
  • Module co-ordinator for AS2095 Human Cytology and Histology
  • Module co-ordinator for AS4020 Genomics and Proteomics
  • MPharm admissions tutor
  • Member of PALS School Learning Enhancement Team
  • Member of university HEA accredited Professional Teaching Framework assessment board
  • Deputy chair of School of Pharmacy and Life sciences (PALS) ethics committee
  • Member of strategic Protection Interprofessional Education (PIPE) group.

Academic Background

  • 2015 Senior Fellow of the Higher Education Authority
  • 2011 PGCert Higher Education Teaching and Learning (Dist)
  • 1995 – 2000 PhD, University of Aberdeen, cytochrome P450 expression in normal and neoplastic human brain.
  • 1990 – 1995 BSc (Honours) Biochemistry, Upper Second class, University of Aberdeen.

Originally trained as a Biochemist, Dr McFadyen completed her PhD (Cytochrome P450 expression in normal and neoplastic human brain) from the University of Aberdeen in 2000. In 2004 she moved to Robert Gordon University (RGU), where she has had a number of diverse roles and responsibilities including elected membership of the RGU academic council 2013-2016. She is admission tutor for the Master of Pharmacy (MPharm) degree at Robert Gordon University and also sits on the UK Pharmacy Schools admission forum. 

Dr McFadyen is a founding member of the Scotland-Japan cross party group at the Scottish Parliament. She is a teaching fellow and senior fellow of the higher education academy and also a member of the professional teaching framework at RGU. Externally, Dr McFadyen is a member of the editorial board of the MDPI Biomedicines journal and an associate editor of the Australian Journal of University Teaching and Learning Practice.

Research Interests

Although Dr McFadyen's scientific expertise is in drug metabolism, cancer research and molecular biology, her current interests lie more to the application of science to practice and innovative educational pedagogies.  Her key research interests include:

  • Global perspectives of adverse drug reactions and pharmacovigilance
  • Collaborative international transdisciplinary research
  • Innovation in education
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Current Research

  • Care pathways - Dementia
  • Cultural diversity
  • Transition to university

Funding

  • 2011– 2017 Three small grants from Aberdeen city council £1,500; £4,000, £2,000 Collaborative Aberdeen-Japan Healthcare Research
  • 2011 - 2017 DELTA - £1,000 to aid cultural, diversity and transition

Professional Memberships

  • Senior Fellow of Higher Education Authority
  • British Association of Cancer Research
  • Biochemistry Society

Publications

Peer-reviewed publications

Book Chapter

  1. McFadyen MCE and Murray GI (2008) Chapter4, The CYP1B subfamily, in Cytochromes P450, Role in the Metabolism and Toxicology of Drugs and Other Xenobiotics, ed. C. Ioannides RSC Publishing Issues in Toxicology.

Reviews

  1. McFadyen MCE and Murray GI (2005). Cytochrome P450 1B1: a novel anticancer therapeutic drug. Future Oncology 1 259-263.
  2. Downie D, Rooney PH, McFadyen MCE, and Murray GI (2004), Pharmacogenomics of Cytochrome P450 Enzymes in Tumours. Current Pharmacogenomics 2 243-254.
  3. Rooney P.H, McFadyen MCE, Melvin WT and Murray GI (2004). The Role of Cytochrome P450 in Cytotoxic Bioactivation: Future Therapeutic Directions. Current Cancer Drug Targets 4: 257-265.
  4. McFadyen MCE, Melvin WT and Murray GI (2004) Cytochrome P450 enzymes: Noveloptions for cancer therapeutics. Molecular Cancer Therapeutics 3: 363-371.

Original articles

  1. McFadyen MCE, Watson E.W (2013) Exploring Just-in-Time Teaching 3D Development as a Tool for Enhancing Knowledge and Understanding. Pharmacy, 1, 269-281.
  2. Donald H, McFadyen MCE and Boyle SP (2011) Development and Evaluation of a Novel Interprofessional Learning Activity Addressing the management of Phenylketonuria. . Clinical Education 4, 189-193.
  3. Downie D, McFadyen MCE, Rooney PH, Cruickshank ME, Parkin DE, Miller ID, Telfer C, Melvin WT, Murray GI (2005). Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers. Clinical Cancer Research 11, 7369-7375.
  4. Rooney PH, Boonsong A, McFadyen MCE, McLeod HL, Cassidy J, Murray GI. (2004) The candidate oncogene ZNF217 is frequently amplified in colorectal cancer. Journal of Pathology 204, 282-288.
  5. McFadyen MCE, Melvin WT and Murray GI. (2004) Cytochrome P450 CYP1B1 Activity in Renal Cell Carcinoma. British Journal of Cancer 91, 966-971.
  6. McFadyen MCE, Rooney PH, MelvinWT and Murray G.I. (2003) Quantitative Analysis of the Ah Receptor/Cytochrome P450 CYP1B1/CYP1A1 Signaling Pathway. Biochemical Pharmacology, 65, 1663-1674.
  7. McFadyen MCE, Cruickshank ME, Miller ID, McLeod HL, Melvin WT, Haites NE, Parkin D and Murray GI. (2001) Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. British Journal of Cancer, 85, 242-246.
  8. McFadyen MCE, McLeod HL, Jackson FC, Melvin WT, Doehmer J and Murray GI. (2001) Cytochrome P450 CYP1B1 protein expression a novel mechanism of anti-cancer drug resistance. Biochemical Pharmacology, 62, 207-212.
  9. McFadyen MCE, Breeman S, Payne S, Stirk C, Miller ID, Melvin WT. and Murray GI. (1999) Immunohistochemical localisation of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. Journal of Histochemistry and Cytochemistry, 47,1457-1464.
  10. Cheung YL, Kerr AC, McFadyen MCE, Melvin WT and Murray G.I. (1999) Differential expression of CYP1A1, CYP1A2 CYP1B1 in human kidney tumours. Cancer Letters, 139, 181-186.
  11. Murray GI, McFadyen MCE, Mitchell RT, Cheung YL, Kerr AC and Melvin WT. (1999) Cytochrome P450 CYP3A in human renal cell cancer. British Journal of Cancer, 79, 1836- 1842.
  12. McFadyen MCE Melvin WT. and Murray GI. (1998) Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain. Biochemical Pharmacology, 55, 825-830.
  13. Murray GI, Taylor, MC, McFadyen MCE, McKay JA, Greenlee, WF, Burke, MD. And Melvin, WT (1997) Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Research, 57, 3026-3031.
  14. Morgan CJ, Coutts AGP, McFadyen MC, King TP, and Kelly D. (1996) Characterisation of IGF-I receptors in the porcine small intestine during postnatal development. Journal of Nutritional Biochemistry. 7, 339-347.
  15. King TP, Begbie R, Slater D, McFadyen M, Thom A and Kelly D. (1995) Sialylation of intestinal microvillar membranes in newborn, sucking and weaned pigs. Glycobiology, 5, 525-534
  16. Gregory PC, McFadyen M and Rayner DV. (1995) Control of gastric emptying in the pig: influence of cholecystokinin, somatostatin and prokinetic agents. Experimental Physiology, 80, 159-165.]
  17. Kelly D, King TP, McFadyen M. and Coutts AG. (1993) Effect of preclosure colostrums intake on the development of the intestinal epithelium of artificially reared piglets. Biology of the Neonate, 64, 235-244.
  18. Kelly D, McFadyen M, King TP and Morgan, PJ. (1992) Characterization and autoradiographic localization of the epidermal growth factor receptor in the jejunum of neonatal and weaned pigs. . Reproductive Fertility and Development, 4, 183-191.
  19. Kelly D, King TP, McFadyen M and Travis AJ. (1991b) Effect of lactation on the decline of brush border lactase activity in neonatal pigs. Gut, 32, 386-392.
  20. Kelly D, King TP, Brown DS and McFadyen M. (1991a) Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. Reproductive Nutrition Development, 31, 73-80.
  21. Gregory PC, McFadyen M and Rayner DV. (1990) Pattern of gastric emptying in the pig:relation to feeding. British Journal of Nutrition, 64, 45-58.
  22. Gregory PC, McFadyen M and Rayner DV. (1989c) Relation between gastric emptying and short-term regulation of food intake in the pig. Physiology and Behavior, 45, 677-683.
  23. Gregory PC, McFadyen M and Rayner DV. (1989b) Duodenal infusion of fat,cholecystokinin secretion and satiety in the pig. Physiology and Behavior, 45, 1021-1024.
  24. Gregory PC, McFadyen M and Rayner DV. (1989a) Control of gastric emptying in the pig: influence of duodenal infusions of glucose and emulsified fat. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 74, 109-119.
  25. Gregory PC, McFadyen M and Rayner DV. (1987) The influence of gastrointestinal infusions of glucose on regulation of food intake in pigs. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 72, 525-535
  26. Davidson J, McFadyen MCE and Milne E. (1981) The nutritive-value of the forage pea pisum-arvense CV Rosakrone for laying hens. Journal of Agricultural. Science, 97, 143-146.

Abstracts

  1. McFadyen MCE, Melvin WT and Murray GI. (2003) Anti-cancer drug interaction with cytochrome P450 CYP1B1. British Journal of Cancer, 88 S16 (oral presentation to the annual British Cancer Research Meeting in Bournemouth).
  2. Rooney PH, Boonsong A, McFadyen M, McLeod HL, Cassidy J and Murray GI. (2002) Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. Journal of Pathology, 198 33A.
  3. Rooney P.H, Boonsong A, McFadyen M, McLeod HL, Cassidy J and Murray GI. (2002) Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR. British Journal of Cancer, 86 S32.
  4. McFadyen MCE, Rooney PH, Melvin WT and Murray GI. (2002) Quantitative analysis of the Ah receptor signalling pathway. British Journal of Cancer, 86, S84.
  5. McFadyen MCE, Melvin WT and Murray GI. (2002) Metabolically active cytochromeP450 CYP1B1 in solid tumours: A novel target for chemotherapeutic intervention. British Journal of Cancer, 86 S111.
  6. McFadyen MCE, Cruickshank ME, Miller ID, Melvin WT and Murray GI. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. (2001) Journal of Pathology, 195 17A.
  7. McFadyen MCE, Melvin WT and Murray GI. (2001) Cytochrome P450CYP1b1: A novel mechanism of drug resistance. British Journal of Cancer, 85 19 (oral presentation to the annual British Cancer Research Meeting in Leeds).
  8. McFadyen MCE, Melvin WT and Murray GI. (2000) CYP1B1 Metabolism: A novelmechanism of anti-cancer drug resistance. Drug Metabolism Reviews, 32 (supplement), 80.
  9. McFadyen MCE, Cruickshank ME, Miller ID, McLeod HL, Melvin WT. Haites NE, Parkin D and Murray GI. (1999) Cytochrome P450 CYP1B1: A possible therapeutic target for ovarian cancer. British Journal of Cancer 80 273.
  10. Murray GI, Buchan S, McFadyen MCE, Miller ID, Payne S and Melvin WT. (1999) Cytochrome P450 CYP1B1 in breast cancer. British Journal of Cancer, 81, 9.
  11. Rochat B, McFadyen MCE, Murray GI and McLeod HL. (1999) Is tumor-specific CYP1B1 expression an unrecognized source of drug resistance? Clinical Cancer Research, 5 573.
  12. Mitchell RT, McFadyen MCE, Cheung YL, Melvin WT and Murray GI, (1998) Cytochrome P450 in Renal cell cancer. Journal of Pathology, 55 825-830.
  13. McFadyen MCE, Melvin WT and Murray GI. (1998) Cytochrome P450 in human brain tumours. British Journal of Cancer, 78, 141-158.
  14. McFadyen MCE, Melvin WT and Murray GI. (1997) Cytochrome P450 in normal human brain and brain tumours. Biochemical Society Transactions, 25, S577.
  15. Gregory PC, McFadyen M and Rayner DV, (1988) Regulation of stomach emptying in pigs. Journal of Physiology-London, 396, P18.

Published letters

  1. Lohr M, McFadyen MCE, Murray GI, Melvin WT (2004). Cytochrome P450 enzymes and tumour therapy. Molecular Cancer Therapeutics. 3, 1503-1504.
  2. McFadyen MCE, Murray G.I and Melvin WT. (1999) Cytochrome P450 CYP1B1 mRNA in normal human brain. Molecular Pathology. 52, 164.

Conference proceedings

  1. Joseph, S. Diack, L., McFadyen, M., Haxton, J., Walker, P., Abe, K., Suematsu, M., Park, H.J. and Yasui, H., 2014. Playing games in interprofessional education: A Japanese and Scottish experience. All Together Better Health VII Conference. 6-8 June 2014. Pittsburgh, Pennsylvania, USA: Pittsburgh University.
  2. Joseph S, Diack L, Haxton J, and McFadyen MCE. 2012. Diversity in Interprofessional Education: Disciplines and Topics. All Together Better Health VI, The 6 th International Conference for Interprofessional Education and Collaborative Practice Exploring New Horizons: Diversity and Quality in Interprofessional Education and Collaborative Practice, 5 th-8th October 2012, Kobe Gakuin University, Kobe, Japan.
  3. McFadyen, MCE. Joseph S, Diack L, and Haxton J 2012. Interprofessional Basic Life Support, Oral Poster. All Together Better Health VI, The 6 th International Conference for Interprofessional Education and Collaborative Practice Exploring New Horizons: Diversity and Quality in Interprofessional Education and Collaborative Practice, 5 th-8th October 2012, Kobe Gakuin University, Kobe, Japan.
  4. Diack L, Joseph S, Haxton J, and McFadyen MCE. 2012. Using online communities to developing IPE in practice. All Together Better Health VI, The 6 th International Conference for Interprofessional Education and Collaborative Practice Exploring New Horizons: Diversity and Quality in Interprofessional Education and Collaborative Practice, 5 th-8th October 2012, Kobe Gakuin University, Kobe, Japan.
  5. Haxton, J. Joseph S, Diack L, and McFadyen MCE. 2012. Interprofessional Education in Practice. All Together Better Health VI, The 6 th International Conference for Interprofessional Education and Collaborative Practice Exploring New Horizons: Diversity and Quality in Interprofessional Education and Collaborative Practice, 5 th-8 th October 2012, Kobe Gakuin University, Kobe, Japan.
  6. Hogan D, Lamb A.J, McFadyen M.C.E. (2010) Antimicrobial effect of Patchouli essential oil (Pogostemon cablin), alone and in combination with chlorhexidine. Novel Antimicrobial Agents, School of Pharmacy and Life Sciences and Research Institute for Health and Welfare, Robert Gordon University, Aberdeen
  7. PICAMILHO-RUA N, Hogan D, Lamb A.J, McFadyen M.C.E. (2010) Antimicrobial activity of Bog myrtle (Myrica Gale) essential oil against Staphylococcus epidermidis and Staphylococcus aureus.
  8. Warasiha B, Knott R, McFadyen M. (2008) Differential Regulation Of CYP4Z1 mRNA In Human Breast Cancer Cell Lines. NCRI National Cancer Conference Birmingham. . NCRI National Cancer Conference Birmingham.
  9. Warasiha B, Knott R, McFadyen M. (2007) Comparative analysis of Cytochrome P450 mRNA Expression between Human Caucasian and Afro-Caribbean Breast Cancer Cell Lines. NCRI National Cancer Conference Birmingham. . NCRI National Cancer Conference Birmingham.
  10. Warasiha B, Knott R, McFadyen M. (2007) Differential Cytochrome P450 mRNA Profile between Non-invasive and Invasive Breast Cancer Phenotypes. NCRI National Cancer Conference Birmingham.
  11. Warasiha B, Knott R, McFadyen M. (2006) Profile of cytochrome P450 mRNA expression in oestrogen positive and negative breast cancer cell lines. NCRI National Cancer Conference Birmingham.
  12. McFadyen MCE, Melvin WT and Murray GI. (2005) Quantitative profiling of CYP3A4 and CYP3A5 mRNA in ovarian cancer. NCRI National Cancer Conference Birmingham.
  13. McFadyen MCE, Melvin WT and Murray GI. (2002) Cytochrome P450 Enzymes: Novel Therapeutic Targets. BACR Special Conference, Cancer Drug Discovery: The Molecular Target/Chemistry Interface Oxford.
  14. McFadyen MCE, Melvin WT and Murray GI. (2002) Metabolically active cytochrome P450CYP1B1 in solid tumours: A novel target for chemotherapeutic intervention. British Association for Cancer Research Meeting Glasgow.
  15. McFadyen MCE, Breeman S, Miller ID, Melvin WT and Murray GI. (1999) Expression of cytochrome P450 CYP1B1 in ovarian cancer Biochemical Society Meeting, Glasgow.
  16. McFadyen MCE, Melvin WT and Murray GI. (1998) Cytochrome P450 expression in normal and neoplastic human brain at the 12th International Symposium on Microsomes and Drug Oxidations. Montpellier, France.

Invited talks

  1. 15th International Conference on Cytochrome P450 Biochemistry 2007, Biophysics and Functional genomics. Bled, Slovenia.
  2. Drug Resistance workshop 2005 Wolfson centre, Hammersmith Hospital, London.

Intellectual property

  1. Murray GI, Melvin WT, McFadyen MCE. Use of CYP1B1 inhibitors for treating cancer. WO01/58444 A1 (PCT GB 01/00548, US2003162727).

Research awards

  1. Poster session prize winner DMW/ISSX 2000 St Andrews, Scotland
  2. McFadyen, M.C.E., Melvin, W.T., Murray, G.I., 2000- CYP1B1 Metabolism: A novel mechanism of anti-cancer drug resistance, at the International Society for the Study of Xenobiotics 2000 Meeting St Andrews.
  3. Metabolism: A novel mechanism of anti-cancer drug resistance, at the International Society for the Study of Xenobiotics 2000 Meeting St Andrews.

Technical Report

  1. Playing games for Interprofessional education: A Scottish Japanese Collaboration. Lesley Diack; Sundari Joseph; Jen Haxton; Morag McFadyen Report number: 1, Affiliation: Sasakawa Foundation

Teaching

As a Biochemist and Senior Fellow of the Higher Education academy at the School of Pharmacy and Life sciences, Dr McFadyen teaches across the School on the bioscience, biomedical science, nutrition and dietetics; forensic and analytical sciences and the Master of Pharmacy degrees.

In her role at RGU, Dr McFadyen has developed a variety of interactive and online support measures to help students fully engage in their degrees. These have been well received internal and external to the university, gaining an invite from Qatar University to provide a pedagogical innovations webinar to Faculty.