|Surname:||Kong Thoo Lin|
|Telephone:||+44 (0) 1224 262818|
Roles and Responsibilities
- Pharmaceutical Teaching Group Leader
- Lecturer in Organic Chemistry, Drug Synthesis, Spectroscopy and Medicinal Chemistry
- Member of the Knowledge Transfer sub-committee for the Faculty of Health & Social Care
- European coordinator of the School of Pharmacy and Life Sciences
- Senior researcher at the Institute for Health and Wellbeing Research
Key research interests
Professor Kong's research interests are to acquire and develop scientific knowledge in order to improve the quality of life. To date, the main focus of his research has been to design and synthesise or isolate from natural sources novel bioactive compounds with functionality to (i) detect and treat diseases and (ii) develop new technology for the improvement of the environment. Key areas of interest include:
- Anti-cancer, anti-parasitic and antioxidant therapeutics read more
- Drug formulation development read more
- Bioactive compounds from natural sourcesread more
Projects and Funding
Professor Kong has actively collaborated with other institutes with common research interests. These include: The Rowett Institute University of Aberdeen; Fachhochschule Bonn-Rhein-Sieg, Rheinbach, Germany; Faculty of Pharmacy, University of Porto, Portugal; The Feinstein Institute for Medical Research, New York, USA and INSERM, Faculté de Médecine-Timone, Marseille, France.
To support the above research and commercial developments, grants had been obtained from the following: The Royal Society, The Wellcome Trust, The Medical Research Council, The Royal Society of Chemistry, The British Council and The Scottish Enterprise Grampian and The Rowett Research Services. Professor Kong and his team(s) have also exploited novel chemical entities for their commercial applications. Examples include:
- Novel macrocyclic system has been used to construct a membrane sensor for the selective detection of nitrate ions; and
- The use of the membrane sensor in an Ion Selective Electrode was applied to determine nitrate levels in vegetables and bottle water [22, 23].
Professor Kong lectures in Organic Chemistry, Drug Synthesis, Spectroscopy and Medicinal Chemistry and supervises PhD projects in a number of topic areas. Potential PhD projects include:
- Targeting Histone Deacetylase Enzyme with novel Bisnaphthalimido propyldiaminoalkanes in cancer cell lines
- The design, synthesis and evaluation of novel macrocyclic catalytic antioxidants
- Natural Products designed Anti-inflammatory Therapeutics
- Design and synthesis of multi target molecules against Cancer
- Chemical profiling and biological activities of fruit pomace extracts
- 1983 BSc (Hons.) Physical Sciences
- 1986 PhD Organic Synthesis
- 1986 Part-time Lecturer, RGIT
- 1987 Post Doctoral Fellow, Medical Research Council, Laboratory of Molecular Biology, Cambridge
- 1992 Lecturer, School of Applied Sciences, Robert Gordon University
- 1999 Reader, School of Pharmacy and Life Sciences, Robert Gordon University
- 2010 Professor, School of Pharmacy and Life Sciences, Robert Gordon University
- Lynda Ralton, Charles S. Bestwick, and Paul Kong Thoo Lin (2007), Polyamine analogues and derivatives as potential anticancer agents. Current Bioactive Compounds, 3 (3), 179-191.
- Vladimir A. Kuksa, Valentin Pavlov, Paul Kong Thoo Lin (2002), Novel Oxa-spermine Homologues: Synthesis and Cytotoxic Properties. Bioorganic & Medicinal Chemistry, 10, 692-697.
- Paul Kong Thoo Lin and Valentin A. Pavlov (2000), The Synthesis and Invitro Cytotoxic Studies of Novel Bis-naphthalimidopropyl Polyamine Derivatives. Bioorganic and Medicinal Chemistry Letters, 10, 1609-1612.
- V. Pavlov, V. Rodilla and P. Kong Thoo Lin (2002). Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells. Life Sciences, 71, 1161-1173.
- P. Kong Thoo Lin, A. M. Dance, C. Bestwick and L. Milne (2003), The biological activities of new polyamine derivatives as potential therapeutic agents. Biochemical Society Transactions, 31, 407-410.
- Valentin Pavlov, Paul Kong Thoo Lin, Vicente Rodilla (2001), Cytotoxic and DNA binding and localisation of novel Bis-naphthalimidopropyl polyamine derivatives. Chemico-Biological Interactions, 137, 15-34.
- Anne-Marie Dance, Lynda Ralton, Zoe Fuller, Charles Bestwick, Lesley Milne, Susan Duthie and Paul Kong Thoo Lin (2005)Synthesis and Biological Activities of Bisnaphthalimido Polyamines Derivatives: Cytotoxicity,DNA Binding, DNA Damage and Drug Localization in Breast Cancer MCF 7 Cells. Biochemical Pharmacology, 69, 19-27.
- Lynda D. Ralton, Susan J. Duthie, Lesley Milne, Paul Kong Thoo Lin and Charles S. Bestwick (2011). The influence of bisnapthalimidopropyl-polyamines on DNA stability and repair in Caco-2 colon epithelial cells. Cell Biology and Toxicology, 27, 455-463. DOI 10.1007/s10565-011-9199-1
- João Oliveira, Lynda Ralton, Joana Tavares, Anabela Codeiro-da-Silva, Charles S. Bestwick, Anne McPherson and Paul Kong Thoo Lin (2007), The Synthesis and the in vitro Cytotoxicity studies of Bisnaphthalimidopropyl Polyamine Derivatives against Colon Cancer Cells and Parasite Leishmania infantum. Bioorganic & Medicinal Chemistry, 15, 541-545.
- Gemma A Barron, Giovanna Bermano, Amanda Gordon, and Paul Kong Thoo Lin (2010). Synthesis, cytotoxicity and DNA binding of novel bisnaphthalimidopropyl polyamine derivatives in breast cancer MDA-MB-231 cells. European Journal of Medicinal Chemistry, 45, 1430-1437.
- Joana Tavares, Ali Ouaissi , Paul Kong Thoo Lin, , Ana Tomás, and Anabela Cordeiro-da-Silva (2005), Differential effects of Polyamine Derivatives Compounds against Leishmania Infantum Promastigotes and Axenic Amastigotes. International Journal for Parasitology, 35, 637-646.
- Joana Tavares, Ali Ouaissi, Paul Kong Thoo Lin, Ines Loureiro, Simranjeet Kaur,Nilanjan Roy, and Anabela Cordeiro-da-Silva (2010). Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1, ChemMedChem., 5, 140-7.
- Joana Tavares, Ali Ouaissi, Ana Marta Silva, Paul Kong Thoo Lin, Nilanjan Roy and Anabela Cordeiro-da-Silva (2011). Anti-leishmanial activity of thebisnaphthalimidopropyl derivatives. Parasitology International doi:10.1016/j.parint.2011.11.005
- Bisnaphthalimidopropyl derivative compounds with anti-parasite and anti cancer activity", PCT/IB2007/052311 was filed in the World Intellectual Property Organisation on the 15th of June 2007 with priority date patent filing of the 19th June 2006. Inventors: , Paul Kong Thoo Lin, Anabela Cordeiro-da-Silva and Joana Tavares.
- Clare Hoskins, Paul Kong Thoo Lin, Laurence Tetley and Woei Ping Cheng (2011). Novel fluorescent amphiphilic poly(allylamine) and their supramacromolecular self-assemblies in aqueous media. Polym. Adv. Technol. 22, 1-10.
- Clare Hoskins, Mehdi Ouaissi, Sofia Costa Lima, Woei Ping Cheng, Inês Loureirio, Eric Mas, Dominique Lombardo, Anabela Cordeiro, Ali Ouaissi and Paul Kong Thoo Lin (2010). In Vitro and in Vivo Anticancer Activity of a Novel nano-sized Formulation based on self-assembling polymers against Pancreatic Cancer. Pharm. Res. 27, 2694-2703.
- Clare Hoskins, Paul Kong Thoo Lin, Laurence Tetley and Woei Ping Cheng (2011).The Use of Nano Self-Assemblies Based on Novel Amphiphilic Graft Polymers for Oral Hydrophobic Drug Delivery. Pharm. Res. ( doi:10.1007/s11095-011-0602-7. )
- Mohammad Shoeb, Sezgin Celik, Marcel Jaspars, Yashodharan Kumarasamy, Stephen M. MacManus, Lutfun Nahar, Paul Kong Thoo-Lin and Satyajit D. Sarker (2005) Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii. Tetrahedron, 61, 9001-9006.
- Mohammad Shoeb, Stephen M. MacManus, Marcel Jaspars, Jioji Trevidu, Lutfun Nahar, Paul Kong Thoo Lin and Satyajit D. Sarker (2006), Montamine, a unique dimeric indole alkaloid, from the seeds of Centaurea montana (Asteraceae), and its in vitro cytotoxic activity against CaCo-2 colon cancer cells. Tetrahedron, 62, 11172-11177.
- Mohammad Shoeb, Sezgin Celik, Lutfun Nahar, Stephen M. MacManus, Paul Kong-Thoo-Lin, Marcel Jaspars, and Satyajit D. Sarker (2007), Two Salonitenolide Derivatives from Aerial Parts of Centaurea gigantea Inhibit the Growth of Colorectal Cancer Cells in vitro. Natural Products Communications, 2, 121-125.
- Peter Kusch, Susanne Deininger, Sabine Specht, Rudeka Maniako, Stefanie Haubrich, Tanja Pommerening, Paul Kong Thoo Lin, Achim Hoerauf and Annette Kaiser (2011). In vitro and in vivo antimalarial activity assays of seeds from Balanites Aegyptiaca: Compounds of the extract show growth inhibition and activity against plasmodial aminopeptidase. Journal of Parasitology Research, doi:10.1155/2011/368692.
- Paul Kong Thoo Lin, Alabert N. Araujo, Maria C.B.S.M. Montenegro and R. Pérez-Olmos (2005). New PVC nitrate-selective electrode: Application to vegetables and mineral waters. Journal of Agricultural and Food Chemistry, 53, 211 – 215.
- Patent WO 02/099409 A1 (PCT/GB02/02292), IP title: Method and application. Inventors: Paul Kong Thoo Lin, Alabert N. Araujo, Maria C.B.S.M. Montenegro. International filing date 5 June 2002.